Publications

Last update : 6th. May. 2011

73. Asymmetric synthesis of 1-deoxyazasugars from chiral aziridines, Org. Biomol. Chem., 2011, 9, 1372
Alok Singh, Bongchan Kim, Won Koo Lee*, and Hyun-Joon Ha* A general and facile ...
72. Chiral aziridine-2-carboxylates: versatile precursors for functionalized tetrahydroisoquinoline (THIQ) containing heterocycles, Tetrahedron 68 (2012) 883-893
Kyu Myung Lee, Jong Chan Kim, Philjun Kang, Won Koo Lee*, Heesung Eum, Hyun-Joon Ha...
71. 3,4-Disubstituted oxazolidin-2-ones as constrained ceramide analogs with anticancer activities. Bioorganic & Medicinal Chemistry 19 (2011) 6174–6181
Alok Singh, Hyun-Joon Ha, Jungchan Park, Jun Hee Kim, Won Koo Lee Heterocyclic an...
70. N-Methylative aziridine ring opening and asymmetric synthesis of MeBmt. Tetrahedron Letters 52 (2011) 5918–5920
Yongeun Kim, Doo-Ha Yoon, Hyun-Joon Ha, Kyung Yeon Kang, Won Koo Lee Asymmetric syn...
69. Regiochemical Pathway in the Ring Opening of 2-Acylaziridines. Bull. Korean Chem. Soc. 2011, Vol. 32, No. 8 2879
Cheol-Min Yook, Heesung Eum, Hyun-Joon Ha,* Kyung Yeon Kang,‡ and Won Koo Lee‡,* T...
68. Synthesis of 1,2,5-and 1,2,3,5-substituted pyrroles from substituted aziridines via Ag(I)-catalyzed intramolecular cyclization , Tetrahedron 67 (2011) 3553-3556.
Jun Hee Kim, Sang Bin Lee, Won Koo Lee, Doo-Ha Yoon, Hyun-Joon Ha　　　　　　　　...
67. Aminostyrylbenzofuran derivatives as potent inhibitors for Aβ fibril formation-BMCL, 2008, 18, 5591-5593
Ji Hun Byun, HyeYun Kim, YoungSoo Kim, Inhee Mook-Jung, Dong Jin Kim, Won Koo Lee, ...
66. An efficient synthesis of enantiomerically pure aromatic-fused N-containing heterocycles from common chiral aziridines - Tetrahedron, 2010, 66, 8108-8114
Jong Chan Kim, Hwan Geun Choi, Min Suk Kim, Hyun-Joon Ha, Won Koo Lee　　　　...
65. A formal synthesis of (-)-swainsonine from a chiral aziridine - Tetrahedron Lett. 2010, 51, 3284
Hwan Geun Choi,Ji Hye Kwon,Jong Chan Kim, Won Koo Lee, Heesung Eum, Hyun-Joon Ha 　...
64. Conjugate addition of amines to chiral 3-aziridin-2-yl-acrylates - Tetrahedron Lett. 2010, 2181
Doo-Ha Yoon, Hyun Joon Ha, Bong Chan Kim, Won Koo Lee 　　　　　　　　　　　　　　　...
63. Synthesis of substituted imidazolidin-2-ones as aminoacyl-tRNA synthase inhibitors - Bull.Kor.Chem.Soc. 2010, 611
Heesung Eum,Yuno Lee,Songmi Kim,Ayoung Baek,Minky Son,Keun Woo Lee,Seung Whan Ko,Sunghoo...
62. Molecular docking study of aminoacyl-tRNA synthetases with ligand molecules from four different scaffolds - Bull.Kor.Chem.Soc 2010, 606
Nagakumar Bharatham, Kavitha Bharatham, Yuno Lee, Songmi Kim, Prettina Lazar, Ayoung Baek, ...
61. Molecular basis for the stereoselective ammoniolysis of N-alkyl aziridine-2-carboxylates catalyzed by Candida antarctica lipase B - ChemBioChem 2009, 10, 2213
Jae-Hoon Park, Hyun-Joon Ha, Won Koo Lee, Tobie Genereux-Vincent, and Romas J.Kazlaus...
60. Synthesis of D-erythro-sphingosine from D-ribo-phytosphingoshine - Bull. Kor. Chem. Soc. 2009, 535
Hyun-Joon Ha, Doo-Ha Yoon, Lae-Sung Kang, Myeng Chan Hone, and Won Koo Lee 　　　...
59. [Synthetic ceramide analogs for anticancer agents] in Glycolipids New Research, Nova Science Pub. New York, 2008, 145- 156
Hyun-Joon Ha, Won Koo Lee and Jungchan Park　　　　　　　　　　　　　　　　　　　　　　　　...
58. Asymmetric formal synthesis of (-)-formoterol and (-)-tamsulosin - Heterocycles - 2007, 2243
Yongeun Kim, Lae-sung Kang, Hyun-Joon Ha, Seung Whan Ko, and Won Koo Lee　　　　　　　...
57. Preparation of enantiopure 2-acylazetidines and their reactions with chloroformates - Tetrahedron Lett. 2007 48 269-271
Sang-ho Ma, Doo Ha Yoon, Hyun-Joon Ha, and Won Koo Lee　　　　　　　　　　　　　　　　...
56. Selective reduction of C-C double bonds of 2-vinylaziridines:preparation of enantiomerically pure 2-alkylaziridines - Bull. Kor. Chem. Soc. 2009, 3123
Baeck Kyoung Lee, Bong June Sung, Won Koo Lee, Doo-Ha Yoon, and Hyun-Joon Ha　　　...
55. Dynamic Thermodynamic Resolution:Advantage by Separation of Equilibration and Resolution - Acc. Chem. Res., 2009, 42, 224
WON KOO LEE, YONG SUN PARK, AND PETER BEAK　　　　　　　　　　　　　　　　　　　...
54. The preparation of stable aziridinium ions and their ring-openings - Chem. Comm. 2008, 4363–4365
Yongeun Kim, Hyun-Joon Ha, Sae Young Yunb, Won Koo Lee　　　　　　　　　　　　　　　　　...
53. Nucleophilic substitution of (sulfonyloxymethyl)aziridines: an asymmetric synthesis of both isomers of mexiletine - Tetrahedron 2008, 64, 11110
Sang-Mi Han, Sang-ho Ma, Hyun-Joon Ha, Won Koo Lee　　　　　　　　　　　　　　　　　　　...
52. Sphingosine 1-phosphate (S1P) induces shape change in rat C6 glioma cells through the S1P2 receptor: development of an agonist for S1P receptors - Journal of Pharmacy and Pharmacology 2007, 59, 1035-1041
Kim, Kyeok; Kim, Yu-Lee; Sacket, Santosh J.; Kim, Hyo-Lim; Han, Mijin; Park, Deok Seong;...
51. Selective Mono-BOC Protection of diamines - Synth. Comm. 2007, 37, 737-742
Dae Woo Lee, Hyun-Joon Ha and Won Koo Lee　　　　　　　　　　　　　　　　　　　　　　　　...
50. Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Aβ fibril formation - Bioorg. Med. Chem. Lett. 2007, 17, 1466-1470
Seong Rim Byeon,Ji Hoon Lee,ji-Hoon Sohn,Dong Chan Kim,Kye jung Shin,Kyung Ho Yoo,...
49. Dihydroxylation of 2-vinyl-aziridine: Efficient synthesis of D-ribo-phytosphingosine - Chem. Commun. 2007, 79-81
Hyo Jae Yoon, Yong-Woo Kim, Baeck Kyoung Lee, Won Koo Lee, Yongeun Kim and Hyun-Joo...
48. Ring opening of 2-acylaziridines by acid chlorides - Tetrahedron 2006, 62, 8844-8849
Yongeun Kim, Hyun-Joon Ha, Hoseop Yun, Baeck Kyoung Lee and Won Koo Lee　　　　　　　...
47. An efficient synthesis of chiral terminal 1,2-diamines using an enantiomerically pure [1-(10R)-methylbenzyl]aziridine-2-yl]methanol - Tetrahedron 2006, 62, 8393-8397
Baeck Kyoung Lee, Min Sung Kim, Heung Sik Hahm, Dong Sub Kim, Won Koo Lee and Hyun...
46. Cyclo(Phe-Pro) Modulates the Expression of ompU in Vibrio spp. - Journal of Bacteriology 2006, 188, 6, 2214
Dae-Kyun Park, Ko-Eun Lee, Chang-Ho Baek, In Hwang Kim, Ji-Hyoun Kwon, Won Koo Lee, ...
45. Synthesis of constrained ceramide analogs and their potent antileukemic activities - Bioorg. Med. Chem. Lett. 2006, 16, 1880-1883
Hyun-Joon Ha, Myeng Chan Hong, Seung Whan Ko, Yong Woo Kim, Won Koo Lee, and Jun...
44. Addition reactions to chiral aziridine-2-carboxaldimine toward various enantiopure nitrogen-containing heterocycles - Tetrahedron. 2005, 9281
Heui-Yoon Noh, Wang-Woo, Seong In Paek, Hyun-Joon Ha, Hoseop Yun and Won Koo Lee...
43. Synthesis of Functionalized Bicyclic Triazoles from Chiral Aziridines - Synlett. 2005, 14, 2187
Min Sung Kim, Hyo Jae Yoon, Baeck Kyoung Lee, Ji Hyun Kwon, Won Koo Lee, Yongeun ...
42. Lewis acid-catalyzed stereospecific ring expansion of aziridine-2-carboxylates to imidazolidin-2-ones - Chem. Commun. 2005, 24, 3062
Min Sung Kim, Yong-Woo Kim, Heung Sik Hahm, Jae Won Jang, Won Koo Lee and Hyun-Joon...
41. Preparation of 2,3-diaminopropionate from ring opening of aziridine-2-carboxylate - Tetrahedron Lett. 2005, 46, 4407
Yongeun Kim,Hyun-Joon Ha,Kyusung Han,Seung Whan Ko,Hoseop Yun,Hyo Jae Yoon Min Sung K...
40. Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases - Bioorg. Med. Chem. 2005, 13, 3475
Jin-Wook Kim, Yong-Woo Kim, Yuichi Inagaki, You-A Hwang, Susumu Mitsutake, Yeon-Woo Ryu, ...
39. Stereoselective Addition of Nucleophiles to Aziridinyl-2-carboxaldimine - Bull. Kor. Chem. Soc. 2004, 1617
Sang-Woo Kim, Heui-Yoon Noh, Seong In Paek, Hyun-Joon Ha, and Won Koo Lee　　　　　...
38. Synthesis and antibacterial activity of arylpiperazinyl oxazolidinones with diversification of the N-substituents - Bioorg. Med. Chem. 2004, 3881
Sun-Young Jang, Young Hwan Ha, Seung Whan Ko, Wonku Lee, Jongkook Lee, Sunghoon Kim, ...
37. Highly Stereoselective Addition of Organomagnesium Reagents to Aziridinyl-2-carboxaldimine: Preparation of Enantiopure 2-Aminomethylaziridines and 4,5-Disubstituted Imidazolidin-2-ones - Synlett. 2004, 489
Man-Jin Suh, Sang Woo Kim, Seong In Beak, Hyun-Joon Ha, Won Koo Lee　　　　　　　　　...
36. Dicyano{[(1S)-(1-phenylethyl)aziridine-2-yl]methanolato-κ2N,O}boron - Acta Cryst. (2003). C59, 0659-0660
Yongkwan Dong, Hoseop Yun, Chan Sun Park, Won Koo Lee, Hyun-Joon Ha　　　　　　　　　...
35. Efficient Synthesis of Enantiomerically Pure 2-Acylaziridines - J. Org. Chem. 2003, 68, 7675
Jung Min Yun,Tae Bo Sim, Heung Sik Hahm, Won Koo Lee, and Hyun-Joon Ha　　　　　　　...
34. Hightlights of the Chemistry of Enantiomerically Pure Aziridine-2-Carboxylates - Aldrichimica Acta 2003, 36, 57
Won Koo Lee and Hyun-Joon Ha　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　...
33. A Novel Synthesis of 5-Functionalized Oxazolidin-2-ones from Enantiomerically Pure 2-Substituted N-[(R)-(+)-r-Methylbenzyl]aziridines - J. Org. Chem. 2003, 68, 104
Tae Bo Sim, Se Hun Kang, Kun Su Lee, Won Koo Lee, Hoseop Yun, Yongkwan Dong, an...
32. Novel Stereoselective Synthesis of Functionalized Oxazolidinones from Chiral Aziridines - J. Org. Chem. 2003, 68, 43
Chan Sun Park,Min Sung Kim,Tae Bo Sim,Do Kyu Pyun,Cheol Hae Lee,and Won Koo Lee ...
31. Facile synthesis of β-anilinopropionates from lewis acid-induced N-methyleneanilines with ketene acetals - Syn. Comm. 2002, 32, 1495
Hyun-Joon Ha, Chang-Ju Choi, and Won Koo Lee　　　　　　　　　　　　　　　　　　　　　　　　...
30. An Efficient Synthesis of N-Boc-D-Diphenylalanine from A Chiral Aziridine-2-Carboxylate - Heterocycles 2002, 57, 1143
Jae-Won Chang, Hyun-Joon Ha, Chan Sun Park, Min Sung Kim, and Won Koo Lee　　　　　...
29. Syntheses of 1b -Methylcarbapenems Bearing 5-Methyl-4-hydroxypyrrolidinone - Chem. Pharm. Bull. 2002, 50, 415
Do Kyu Pyun, Bong Jin Kim, Hee Jung Jung, Jae Hak Kim, Jin Soo Lee, Won Koo Lee, ...
28. Synthesis and SAR of Aziridinylquinoline-5,8-diones as Agents against Malignant Tumor Cells - Bull. Kor. Chem. Soc. 2001, 22, 1067
Kyung Ho Yoo, Eun Young Yoon, Yoon Young Park, Sang Woo Park, Chong-Ock Lee, Won ...
27. Synthesis of Substituted-(l)-Tryptophanols from an Enantiomerically Pure Aziridine-2-methanol - Org. Lett. 2001, 3, 4197.
Do Kyu Pyun, Cheol Hae Lee, Hyun-Joon Ha, Chan Sun Park, Jae-Won Chang, and Won ...
26. New Uses of Amino Acids as Chiral Building Blocks in Organic Synthesis - Org. Lett. 2001, 3, 3119
Manfred T. Reetz and Won Koo Lee　　　　　　　　　　　　　　　　　　　　　　　　　　　　　...
25. Asymmetric synthesis of β-amino-α-hydroxy acids through Lewis acid-mediated addition of ketone acetal to imines - Bull. Chem. Soc. Jpn. 2001, 74, 1667
Hyun-Joon Ha, Young-Gil Ahn, Jun-Sik Woo, Gwan Sun Lee, and Won Koo Lee　　　　　　...
24. New synthesis and ring opening of cis-3-alkylaziridine-2-carboxylates - Tetrahedron 2001, 57, 9655
Kwang-Deuk Lee, Jang-Min Suh, Jae-Hoon Park, Hyun-Joon Ha, Hwan Gun Choi, Chan Sun P...
23. Synthesis of Quaternary Ammoniocephalosporin Having Two Vinyl Groups Using Radical Promoted Thermal Isomerization - Bull. Kor. Chem. Soc. 2001, 22, 659
Do Kyu Pyun, Bong Jin Kim, Jae Hak Kim, Hee Jung Jung, Jae Hoon Kang, Won Koo Lee, ...
22. Selective production of difluoromethyl methyl ether from chlorodifluoromethane using alkali metal carbonates - J. Fluorine Chem. 2001, 107, 133
Hyunjoo Lee, Hoon Sik Kim, Sang Deuk Lee, Won Koo Lee, and Honggon Kim　　 　　　...
21. Cycloaddition of Lewis Acid-Induced N-Methyleneanilines as Azadienes to 1,2-Bistrimethylsilyloxycyclobutene and Oxidative Ring Expansion to 1,2,4,5-Tetrahydro-1-benzazocine-3,6-diones - J. Org. Chem. 2000, 65, 8384
Hyun-Joon Ha,Chang-Ju Choi,Young-Gil Ahn,Hoseop Yun,Yongkwan Dong,and Won Koo Lee　　　...
20. Stereoselective synthesis of enantiomerically pure D-threo-PDMP; manipulation of a core 2,3-diamino alcohol unit - Tetrahedron : Asymmetry 2000, 11, 3283
　　 Seong-Ho Shin, Eun Young Han, Chan Sun Park, Won Koo Lee, and Hyun-Joon Ha ...
19. Stereoselective synthesis of protected threo-β-hydroxy-L-glutamic acid using a chiral aziridine - Tetrahedron : Asymmetry 2000, 11, 3283
Chan Sun Park, Hawn Geun Choi, Hyunjoo Lee, Won Koo Lee and Hyun-Joon Ha　　　　　...
18. Preparation of Cysteinol Derivatives by Highly Regioselective Ring Opening Nonactivated Chiral Aziridines by Thiols - Tetrahedron 1999, 55, 10041
Jae Hyun Bae, Seong-Ho Shin, Chan Sun Park, and Won Koo Lee　　　　　　　　　　　　　...
17. The Thiazole Route to 2-Formyl-1β-Methylcarbapenem - Bull. Kor. Chem. Soc. 1998, 19, 1294
Jin Soo Lee, Do Kyu Pyun, Won Koo Lee, and Cheol Hae Lee　　　　　　　　　　　　　　...
16. Synthesis of Substituted (D)-Phenylalanine Derivatives by Regioselective Reduction of Enantiomerically Pure cis-2,3-Disubstituted Aziridines - Tetrahedron Lett. 1998, 39, 9193
Jae-Won Chang,Jae Hyun Bae,Seong-Ho Shin,Chan Sun Park,Daeock Choi and Won Koo Lee　...
15. Preparation of both (D)- and (L)-serinol derivatives from N-[(S)-a-methylbenzyl]-aziridine-2(S)-methanol - Heterocycles 1998, 48, 1917
Soo-Kyung Choi and Won Koo Lee　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　...
14. A new synthetic route to (3R,4S)-3-hydroxy-4-phenylazetidin-2-one as a taxol side chain precursor - Tetrahedron : Asymmetry 1998, 9, 983
Choong Eui Song, Sung Woo Lee, Eun Joo Roh, Sang-gi Lee and Won Koo Lee　　　　　...
13. Efficient Syntheses of (1R,2R)- and (1S,2S)-2-Amino-1-alkyl(oraryl)-1,3-propanediols by Regioselective Ring Opening of Aziridine-2-methanols - J. Org. Chem. .1997, 743
Soo-Kyung Choi, Jin-Soo Lee, Jung-Ho Kim and Won Koo Lee 　　　　　　　　　　　　　　　　...
12. Highly diastereoselective reduction of enantiomerically pure aziridino ketones - Tetrahedron 1996, 52, 12117
Bong Chan Kim and Won Koo Lee 　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　...
11. An Effcient synthesis of both enantiomers of cathinone by regioselective reductive ring opening of substituted aziridines - Tetrahedron 1996, 52, 12111
Gwon-Il Hwang, Jae-Ho Chung, and Won Koo Lee　　　　　　　　　　　　　　　　　　　　　　　...
10. Efficient Synthesis of Ephedra Alkaloid Analogues Using an Enantiomerically Pure N-[(R)-(+)-r-Methylbenzyl]aziridine-2-carboxaldehyde - J. Org. Chem. 1996, 61, 6183
Gwon-Il Hwang, Jae-Ho Chung, and Won Koo Lee　　　　　　　　　　　　　　　　　　　　　　　　...
9. Resiospecific reductive ring cleavage of N-substituted aziridine-2-carboxylates and an aziridine-2-methanol via catalytic hydrogenation using Pd as a catalyst - Tetrahedron Lett. 1995, 36, 8431
Yeonhwa Lim and Won Koo Lee　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　...
8. Chirospecific Syntheses of Precursors of Cyclopentane and cyclopentene Carbocyclic Nucleosides by [3 + 33-Coupling and Transannular Alkylation - J. Org. Chem. 1995, 60, 4602
Jeffrey A. Campbell, Won Koo Lee, and Henry Rapoport　　　　　　　　　　　　　　　　...
7. Regioselective N-Methyl Carbon Lithiation of N-Boc-MethylalkylaminrylamiEnxepae dient Synthesis of Unsymmetrical Amines - Tetrahedron Lett. 1994, 35, 4067
Victor Snieckus,Mark Rogers-Evans,Peter Beak,Won Koo Lee, Eul Kyun Yum,John Freskos 　...
6. Chirospecific Synthesis of (1S,3R)-l-Amino-3-(hydroxymethyl)cyclopentane a Precursor for Carbocyclic Nucleoside Synthesis. Intramolecular Aziridine Cyclizations - J. Org. Chem. 1993, 58, 5019
Stephen C. Bergmeier, Won Koo Lee, and Henry Rapoport　　　　　　　　　　　　　　　　...
5. a-Lithioamine Synthetic Equivalents: Syntheses of Diastereoisomers from Boc Derivatives of Cyclic Amines - J. Org. Chem. 1993, 58, 1109
Peter Beak and Won Koo Lee 　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　...
4. Endocyclic Restriction Test: Evaluation of Transition-Structure Geometry for an Aryl Bromide-Alkyllithium Exchange Reaction - J. Am. Chem. Soc. 1990, 112, 1629
Peter Beak, David J. Allen and Won Koo Lee　　　　　　　　　　　　　　　　　　　　　...
3. a-Lithioamine Synthetic Equivalents: Syntheses of Diastereoisomers from the Boc Piperidines - J. Org. Chem. 1990, 55, 2578
Peter Beak and Won Koo Lee　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　 ...
2. a-Lithioamine synthetic equivalents from dipole-stabilized carbaniones: The r-Boc group as an activator for a’-Lithiation of carbamates - Tetrahedron Lett. 1989, 30, 1197
Peter Beak and Won Koo Lee 　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　...
1. Regiospecific Alkylation of Allylic Halides with Latent-γ-Functionality - J. Org. Chem. 1984, 49, 1838
Jahyo Kang, Wonoh Cho and Won Koo Lee　　　　　　　　　　　　　　　　　　　　　　　　　...
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